DNA sequence-dependent chromatin architecture and nuclear hubs formation
نویسندگان
چکیده
منابع مشابه
DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear Lamina
A large fraction of the mammalian genome is organized into inactive chromosomal domains along the nuclear lamina. The mechanism by which these lamina associated domains (LADs) are established remains to be elucidated. Using genomic repositioning assays, we show that LADs, spanning the developmentally regulated IgH and Cyp3a loci contain discrete DNA regions that associate chromatin with the nuc...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-51036-9